Title: On the ups and downs of informatics in biotechnology Abstract: Bioinformatics, or - more generally - life science informatics plays a crucial role in the pharmaceutical industry, agricultural research industry, and biotechnology. It offers an unprecedented potential for discovery and benefits, leading to advances ranging from inherently disease resistant crops to personally-tailored, side-effect-free medicines. However, bioinformatics also provides an almost overwhelming array of challenges, due in part to the rapid growth rate of the field which did not allow sufficient time for standards to establish themselves. As a result, two of the greatest technical challenges in bioinformatics are data integration and interoperability of tools. In addition to the technical challenges, the industry also faces the "post-bubble" climate which meant the demise of several large, including one of the four public, bioinformatics companies. This talk will present an overview of the changing landscape of life science informatics, address the technical and business challenges, and attempt a guess at predicting the future of the field. --- Maciek Sasinowski, Ph.D. CEO, INCOGEN, Inc. (Institute for Comptuational Genomics) Williamsburg VA www.incogen.com Bio: Dr. Sasinowski received his PhD in computational plasma physics from the College of William and Mary. He established the Bioinformatics Center at Clemson University's Genomics Institute in 1996. Dr. Sasinowski founded Incogen in 1998, and the company offers bioinformatics software and services to optimize analysis and mining of genomic data. The range of services include software tools for data visualization, image reconstruction, and genomic data mining. Incogen is involved in collaborative projects with the Virginia Bioinformatics Institute and the College of William and Mary. Dr. Sasinowski was recently chosen by the Genome Technology magazine as one of the 15 most influential people under 30 in genomics. --