Title: Estimating tick-borne disease risk with an agent-based model. Ticks have a unique life history including a distinct set of life stages and a single bloodmeal per life stage. While some tick species have a single preferred host for each life stage, other tick species will feed on a variety of hosts. All of this makes tick-host interactions more complex from a mathematical perspective. In addition, any model of these interactions must involve a significant degree of stochasticity on the individual tick level. In an attempt to quantify these relationships, we have developed an individual-based model of the interactions between ticks and their hosts as well as the transmission of tick-borne disease between the two populations. Preliminary analysis of disease prevalence as a function of host diversity is presented. Dr. Holly Gaff is an Assistant Professor in the Department of Biological Sciences at Old Dominion University and is affiliated with the Virginia Modeling, Analysis and Simulation Center. Dr. Gaff earned her Ph.D. in Mathematics at the University of Tennessee, Knoxville, in 1999. Dr. Gaff's research interests have focused mainly on studying the dynamics and control of infectious diseases using mathematical modeling and computer simulation. Most of her research has focused on developing mathematical models for exploring the ecology of vector-borne diseases including Rift Valley fever and tick-borne diseases in the Hampton Roads area. She has had funding for these and other projects from NIH, NSF, DHS, CDC and the VA.